Add to ORKGBackground A novel, swine-origin influenza A (H1N1) virus was detected worldwide in April 2009, and the World Health Organization (WHO) declared a global pandemic that June. DNA vaccine priming improves responses to inactivated influenza vaccines. We describe the rapid pro-duction and clinical evaluation of a DNA vaccine encoding the hemagglutinin protein of the 2009 pandemic A/California/04/2009(H1N1) influenza virus, accomplished nearly two months faster than production of A/California/07/2009(H1N1) licensed monovalent inacti-vated vaccine (MIV). Methods 20 subjects received three H1 DNA vaccinations (4 mg intramuscularly with Biojector) at 4-week intervals. Eighteen subjects received an optional boost when the licensed H1N1 MIV became av...
INTRODUCTION: Influenza is a major respiratory viral infection of humans with high mortality and mor...
Background and Objectives Influenza A viruses cause highly contagious diseases in a variety of hosts...
BackgroundSeasonal influenza results in significant morbidity and mortality worldwide, but the curre...
A novel, swine-origin influenza A (H1N1) virus was detected worldwide in April 2009, and the World H...
A novel, swine-origin influenza A (H1N1) virus was detected worldwide in April 2009, and the World H...
BackgroundA novel, swine-origin influenza A (H1N1) virus was detected worldwide in April 2009, and t...
The efficacy of current influenza vaccines is limited in vulnerable populations. DNA vaccines can be...
million people worldwide. Immunization with 1918-like and classical swine H1N1 virus vaccines result...
The 2009 “swine flu” pandemic outbreak demonstrated the limiting capacity for egg-based vaccines wit...
This is an open access article distributed under the Creative Commons Attribution License, which per...
The highly pathogenic avian influenza virus H5N1 is a potent pandemic threat because of its frequent...
The challenges of effective vaccination against influenza are gaining more mainstream attention, as ...
An outbreak of influenza H1N1 in 2009, representing the first influenza pandemic of the 21st century...
Introduction: Influenza is a major respiratory viral infection of humans with high mortality and mor...
Avian influenza virus causes outbreaks in domestic and wild birds around the world, and sporadic hum...
INTRODUCTION: Influenza is a major respiratory viral infection of humans with high mortality and mor...
Background and Objectives Influenza A viruses cause highly contagious diseases in a variety of hosts...
BackgroundSeasonal influenza results in significant morbidity and mortality worldwide, but the curre...
A novel, swine-origin influenza A (H1N1) virus was detected worldwide in April 2009, and the World H...
A novel, swine-origin influenza A (H1N1) virus was detected worldwide in April 2009, and the World H...
BackgroundA novel, swine-origin influenza A (H1N1) virus was detected worldwide in April 2009, and t...
The efficacy of current influenza vaccines is limited in vulnerable populations. DNA vaccines can be...
million people worldwide. Immunization with 1918-like and classical swine H1N1 virus vaccines result...
The 2009 “swine flu” pandemic outbreak demonstrated the limiting capacity for egg-based vaccines wit...
This is an open access article distributed under the Creative Commons Attribution License, which per...
The highly pathogenic avian influenza virus H5N1 is a potent pandemic threat because of its frequent...
The challenges of effective vaccination against influenza are gaining more mainstream attention, as ...
An outbreak of influenza H1N1 in 2009, representing the first influenza pandemic of the 21st century...
Introduction: Influenza is a major respiratory viral infection of humans with high mortality and mor...
Avian influenza virus causes outbreaks in domestic and wild birds around the world, and sporadic hum...
INTRODUCTION: Influenza is a major respiratory viral infection of humans with high mortality and mor...
Background and Objectives Influenza A viruses cause highly contagious diseases in a variety of hosts...
BackgroundSeasonal influenza results in significant morbidity and mortality worldwide, but the curre...