RESEARCH ARTICLE Increased Insulin following an Oral Glucose Load, Genetic Variation near the Melatonin ReceptorMTNR1B, but No Biochemical Evidence of Endothelial Dysfunction in Young Asian Men and Women

Aim To identify biochemical and genetic variation relating to increased risk of developing type 2 diabetes mellitus and cardiovascular disease in young, lean male and female adults of dif-ferent ethnicities. Method Fasting blood and urine and non-fasting blood following oral glucose intake were analysed in 90 Caucasians, South Asians and South East/East Asians. Results There were no differences in age, birthweight, blood pressure, body mass index, percent body fat, total energy, percentage of macronutrient intake, microalbumin, leptin, cortisol, adrenocorticotropic hormone, nitric oxide metabolites, C-reactive protein, homocysteine, tumor necrosis factor-α, interleukin-6, von Willebrand factor, vascular cell adhesion mole-cule-1, plasminogen activator inhibitor-1, and tissue plasminogen activator. Fasting total cholesterol (P =.000), triglycerides (P =.050), low density lipoprotein (P =.009) and non