SANSparallel: interactive homology search against

Proteins evolve by mutations and natural selec-tion. The network of sequence similarities is a rich source for mining homologous relationships that in-form on protein structure and function. There are many servers available to browse the network of homology relationships but one has to wait up to a minute for results. The SANSparallel web-server provides protein sequence database searches with immediate response and professional align-ment visualization by third-party software. The out-put is a list, pairwise alignment or stacked align-ment of sequence-similar proteins from Uniprot, UniRef90/50, Swissprot or Protein Data Bank. The stacked alignments are viewed in Jalview or as se-quence logos. The database search uses the suffix array neighborhood search (SANS) method, which has been re-implemented as a client-server, im-proved and parallelized. The method is extremely fast and as sensitive as BLAST above 50 % se-quence identity. Benchmarks show that the method is highly competitive compared to previously pub-lished fast database search programs: UBLAST, DI-AMOND, LAST, LAMBDA, RAPSEARCH2 and BLAT. The web server can be accessed interactively or pro-grammatically a