Korea

in urine concentration mechanism Urea is an abundant solute in the mammalian renal medulla and the accumulation of urea is important for the generation of concentrated urine. The concentra-tion of urea in the inner medulla is produced by the recycling of urea, secretion into the ascending thin limb (ATL) of the Henle s loop via the UT-A2 urea’ transporter, and reabsorption in the inner medullary collecting duct (IMCD) via UT-A1 urea transporter1)