Add to ORKGBackground: PRDM (PRDI-BF1 and RIZ domain containing) proteins are zinc finger proteins involved in multiple cellular regulations by acting as epigenetic modifiers. We studied a recently identified PRDM member PRDM5 for its epigenetic abnormality and tumor suppressive functions in multiple tumorigeneses. Methodology/Principal Findings: Semi-quantitative RT-PCR showed that PRDM5 was broadly expressed in human normal tissues, but frequently silenced or downregulated in multiple carcinoma cell lines due to promoter CpG methylation
The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype...
The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype...
Multiple myeloma (MM) is a B-cell neoplasm that is characterized by the accumulation of malignant pl...
BACKGROUND: PRDM (PRDI-BF1 and RIZ domain containing) proteins are zinc finger proteins involved in ...
PRDM (PRDI-BF1 and RIZ domain containing) proteins are zinc finger proteins involved in multiple cel...
The PR/SET domain family (PRDM) comprise a family of genes whose protein products share a conserved ...
PRDM6 belongs to PRDM family of proteins, which function both as transcription factors and epigeneti...
epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling...
PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the p...
Epigenetic signalling dictates the dynamic patterns of gene expression that are required for life. I...
An epigenetic drug screen was carried out in CRC organoids which identified PRMT5 as a potential epi...
PRDM genes are a family of transcriptional regulators that modulate cellular processes such as diffe...
Multiple myeloma (MM) is a B-cell neoplasm that is characterized by the accumulation of malignant pl...
The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype...
The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype...
The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype...
Multiple myeloma (MM) is a B-cell neoplasm that is characterized by the accumulation of malignant pl...
BACKGROUND: PRDM (PRDI-BF1 and RIZ domain containing) proteins are zinc finger proteins involved in ...
PRDM (PRDI-BF1 and RIZ domain containing) proteins are zinc finger proteins involved in multiple cel...
The PR/SET domain family (PRDM) comprise a family of genes whose protein products share a conserved ...
PRDM6 belongs to PRDM family of proteins, which function both as transcription factors and epigeneti...
epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling...
PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the p...
Epigenetic signalling dictates the dynamic patterns of gene expression that are required for life. I...
An epigenetic drug screen was carried out in CRC organoids which identified PRMT5 as a potential epi...
PRDM genes are a family of transcriptional regulators that modulate cellular processes such as diffe...
Multiple myeloma (MM) is a B-cell neoplasm that is characterized by the accumulation of malignant pl...
The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype...
The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype...
The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype...
Multiple myeloma (MM) is a B-cell neoplasm that is characterized by the accumulation of malignant pl...