Published on-line:

Introduction Renal cell carcinomas (RCC) are collectively the third most common type of genitourinary neoplasms, surpassed only by prostate and bladder cancer. Cure rates for renal cell carcinoma are related to tumor grade and stage; therefore, diagnostic methods for early detection and new therapeutic modali-ties are of paramount importance. Epigenetics can be defined as inherited modifications in gene expres-sion that are not encoded in the DNA sequence itself. Epigenetics may play an important role in the pursui