Copyright: © Sourbier et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The tumor suppressor gene, Von Hippel-Lindau (VHL), is frequently mutated in the most common form of kidney cancer, clear cell renal cell carcinoma (CCRCC). In hypoxic conditions, or when there is a VHL mutation, the hypoxia inducible factors, HIF1α and HIF2α, are stabilized and transcribe a panel of genes associated with cancer such as vascular endothelial growth factor receptor (VEGFR), platelet derived growth factor (PDGF), and glucose transporter 1 (GLUT1). Recent studies in ...
Objectives: The most frequent genomic abnormality in clear cell renal cell carcinoma (cc-RCC) is ina...
VHL tumor suppressor loss results in hypoxia inducible factor-alpha (HIF-α) stabilization, and occur...
Over the past decade major advances have been made in our understanding of the molecular machinery t...
Patients with Von Hippel-Lindau (VHL) disease develop multiple, synchronous or metachronous clear ce...
The basic biology underlying the development of clear-cell renal cell carcinoma (ccRCC) is criticall...
The clear cell variant of renal cell carcinoma (ccRCC) is the most common renal epithelial malignanc...
Hypoxia-inducible factor (HIF), an important mediator of hypoxia response, is implicated in tumorige...
Hypoxia-inducible factor (HIF) plays an important role in renal tumourigenesis. In the majority of c...
Renal cell carcinoma (RCC) is the commonest urogenital tumor, characterized by increased expression...
Kidney cancer affects over 7000 people each year in the UK and its incidence is rising. The majority...
Von Hipple-Lindau gene (VHL) inactivation represents the most frequent abnormality in clear cell ren...
The role of the von Hippel-Lindau tumor suppressor protein (pVHL) in kidney cancer has provided a ra...
The most common type of the renal cancers detected in humans is clear cell renal cell carcinomas (cc...
Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year ...
Abstract Background In clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of ...
Objectives: The most frequent genomic abnormality in clear cell renal cell carcinoma (cc-RCC) is ina...
VHL tumor suppressor loss results in hypoxia inducible factor-alpha (HIF-α) stabilization, and occur...
Over the past decade major advances have been made in our understanding of the molecular machinery t...
Patients with Von Hippel-Lindau (VHL) disease develop multiple, synchronous or metachronous clear ce...
The basic biology underlying the development of clear-cell renal cell carcinoma (ccRCC) is criticall...
The clear cell variant of renal cell carcinoma (ccRCC) is the most common renal epithelial malignanc...
Hypoxia-inducible factor (HIF), an important mediator of hypoxia response, is implicated in tumorige...
Hypoxia-inducible factor (HIF) plays an important role in renal tumourigenesis. In the majority of c...
Renal cell carcinoma (RCC) is the commonest urogenital tumor, characterized by increased expression...
Kidney cancer affects over 7000 people each year in the UK and its incidence is rising. The majority...
Von Hipple-Lindau gene (VHL) inactivation represents the most frequent abnormality in clear cell ren...
The role of the von Hippel-Lindau tumor suppressor protein (pVHL) in kidney cancer has provided a ra...
The most common type of the renal cancers detected in humans is clear cell renal cell carcinomas (cc...
Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year ...
Abstract Background In clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of ...
Objectives: The most frequent genomic abnormality in clear cell renal cell carcinoma (cc-RCC) is ina...
VHL tumor suppressor loss results in hypoxia inducible factor-alpha (HIF-α) stabilization, and occur...
Over the past decade major advances have been made in our understanding of the molecular machinery t...