Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis. Its overexpression in many human cancers makes it an important target for anti-cancer drugs. Bcl-XL interacts with the BH3 domain of several pro-apoptotic Bcl-2 partners. This helical bundle protein has a pronounced hydrophobic groove which acts as a binding region for the BH3 domains. Eight independent molecular dynamics simulations of the apo/holo forms of Bcl-XL were carried out to investigate the behavior of solvent-exposed hydrophobic groove. The simulations used either a twin-range cut-off or particle mesh Ewald (PME) scheme to treat long-range interactions. Destabilization of the BH3 domain-containing helix H2 was observed in ...
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we descri...
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival member...
<p>The interaction between protein and peptide ligand is a challenging problem in molecular biology ...
The Bcl2 family of proteins is capable of switching the apoptotic machinery by directly controlling ...
AbstractThe balance and interplay between pro-death and pro-survival members of the B-cell lymphoma-...
The Bcl2 family of proteins is capable of switching the apoptotic machinery by directly controlling ...
Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are...
BCL-2 proteins play a significant role in regulating apoptosis through complex interactions between ...
The Bcl2 family of proteins is capable of switching the apoptotic machinery by directly controlling ...
International audienceThe proteins of the Bcl-2 family are important regulators of apoptosis, or pro...
Inhibition of normal cellular apoptosis or programed cell death is the hallmark of all cancers. Apop...
Bcl-XL, an antiapoptotic Bcl-2 family protein, plays a central role in the regulation of the apoptot...
Bcl-X(L), an antiapoptotic Bcl-2 family protein, plays a central role in the regulation of the apopt...
The BclXL apoptotic repressor, a member of the B-cell lymphoma 2 family of proteins, plays a central...
<p>(A) Structure of Bcl-XL in solution. (B) Membrane-integrated conformation of Bcl-XL in which the ...
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we descri...
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival member...
<p>The interaction between protein and peptide ligand is a challenging problem in molecular biology ...
The Bcl2 family of proteins is capable of switching the apoptotic machinery by directly controlling ...
AbstractThe balance and interplay between pro-death and pro-survival members of the B-cell lymphoma-...
The Bcl2 family of proteins is capable of switching the apoptotic machinery by directly controlling ...
Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are...
BCL-2 proteins play a significant role in regulating apoptosis through complex interactions between ...
The Bcl2 family of proteins is capable of switching the apoptotic machinery by directly controlling ...
International audienceThe proteins of the Bcl-2 family are important regulators of apoptosis, or pro...
Inhibition of normal cellular apoptosis or programed cell death is the hallmark of all cancers. Apop...
Bcl-XL, an antiapoptotic Bcl-2 family protein, plays a central role in the regulation of the apoptot...
Bcl-X(L), an antiapoptotic Bcl-2 family protein, plays a central role in the regulation of the apopt...
The BclXL apoptotic repressor, a member of the B-cell lymphoma 2 family of proteins, plays a central...
<p>(A) Structure of Bcl-XL in solution. (B) Membrane-integrated conformation of Bcl-XL in which the ...
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we descri...
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival member...
<p>The interaction between protein and peptide ligand is a challenging problem in molecular biology ...