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Cancer is principally caused by changes in three types of genes i.e. oncogenes, tumor suppressor genes and DNA the immune system are key strategies to control cancer progression and increase effectiveness of treatment [3]. Younis et al. BMC Cancer (2015) 15:369 DOI 10.1186/s12885-015-1337-3[4,5]. These pathways activate transcription factors,2Department of Biochemistry and Molecular Pharmacology, New York, USA Full list of author information is available at the end of the articlestability genes; common environmental factors contribut-ing to these changes could be smoking, oncogenic viruses, occupational and environmental carcinogens and predis-posing genetic polymorphisms [1,2]. Massive research ef-forts are ongoing to find treatments for cancer, still an unresolved problem and of course a heavy burden on EGFR, important growth factor receptor implicated in many cancers, is one of the targets for chemotherapy. EGFR belongs to ErbB family of tyrosine kinase receptor