Background: Phospholipases A2 (PLA2) hydrolyzes phospholipids, initiating the production of inflammatory lipid mediators. We have previously shown that in rats, sPLA2 and cPLA2 play opposing roles in the pathophysiology of ovalbumin (OVA)-induced experimental allergic bronchitis (OVA-EAB), an asthma model: Upon disease induction sPLA2 expression and production of the broncho-constricting CysLTs are elevated, whereas cPLA2 expression and the broncho-dilating PGE2 production are suppressed. These were reversed upon disease amelioration by treatment with an sPLA2 inhibitor. However, studies in mice reported the involvement of both sPLA2 and cPLA2 in EAB induction. Objectives: To examine the relevance of mouse and rat models to understanding as...
Objective Asthma is a chronic inflammatory disease that can lead to severe problems with the respira...
Asthma is a common chronic disease characterized by bronchial inflammation, reversible airway obstru...
Abstract The detailed pathogenesis of eosinophilic bronchitis (EB) remains unclear. Transglutaminase...
BACKGROUND: Phospholipases A2 (PLA2) hydrolyzes phospholipids, initiating the production of inflamma...
Secreted phospholipase A 2 s (sPLA 2 s) regulate eicosanoid formation and have been implicated in as...
Previous work has shown that disruption of the gene for group X secreted phospholipase A2 (sPLA2-X) ...
Background: Previous work has shown that disruption of the gene for group X secreted phospholipase A...
[[abstract]]RATIONALE: In a seemingly complex network of cellular and molecular regulations under st...
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrola...
<div><p>Background</p><p>Phospholipase Cε (PLCε) is an effector of Ras and Rap small GTPases and exp...
regulatory roles in the biosynthesis of eicosanoids, such as the cysteinyl leukotrienes, but the rol...
BACKGROUND: Secreted phospholipases A(2) (sPLA(2)s) are released in plasma and other biologic fluids...
RationaleIndirect airway hyperresponsiveness (AHR) is a fundamental feature of asthma that is manife...
Phospholipases A2 (PLA2s) are enzymes responsible for mobilization of fatty acids, including arachid...
in EAB induction.To examine the relevance of mouse and rat models to understanding asthma pathophys...
Objective Asthma is a chronic inflammatory disease that can lead to severe problems with the respira...
Asthma is a common chronic disease characterized by bronchial inflammation, reversible airway obstru...
Abstract The detailed pathogenesis of eosinophilic bronchitis (EB) remains unclear. Transglutaminase...
BACKGROUND: Phospholipases A2 (PLA2) hydrolyzes phospholipids, initiating the production of inflamma...
Secreted phospholipase A 2 s (sPLA 2 s) regulate eicosanoid formation and have been implicated in as...
Previous work has shown that disruption of the gene for group X secreted phospholipase A2 (sPLA2-X) ...
Background: Previous work has shown that disruption of the gene for group X secreted phospholipase A...
[[abstract]]RATIONALE: In a seemingly complex network of cellular and molecular regulations under st...
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrola...
<div><p>Background</p><p>Phospholipase Cε (PLCε) is an effector of Ras and Rap small GTPases and exp...
regulatory roles in the biosynthesis of eicosanoids, such as the cysteinyl leukotrienes, but the rol...
BACKGROUND: Secreted phospholipases A(2) (sPLA(2)s) are released in plasma and other biologic fluids...
RationaleIndirect airway hyperresponsiveness (AHR) is a fundamental feature of asthma that is manife...
Phospholipases A2 (PLA2s) are enzymes responsible for mobilization of fatty acids, including arachid...
in EAB induction.To examine the relevance of mouse and rat models to understanding asthma pathophys...
Objective Asthma is a chronic inflammatory disease that can lead to severe problems with the respira...
Asthma is a common chronic disease characterized by bronchial inflammation, reversible airway obstru...
Abstract The detailed pathogenesis of eosinophilic bronchitis (EB) remains unclear. Transglutaminase...