The pathogenesis of acute lung injury (ALI) involves bidirectional cooperation and close interaction between inflammatory and coagulation pathways. A key molecule linking coagulation and inflammation is the procoagulant thrombin, a serine protease whose concentration is elevated in plasma and lavage fluids of patients with ALI and acute respiratory distress syndrome (ARDS). However, little is known about the mechanism by which thrombin contributes to lung inflammatory response. In this study, we developed a new mouse model that permits investigation of lung inflammation associated with intravascular coagulation. Using this mouse model and in vitro approaches, we addressed the role of non-muscle myosin light chain kinase (nmMLCK) in thrombin...
The goal of this study was to investigate the role of MLC phosphatase (MLCP) in a LPS model of acute...
The lipopolysaccharide (LPS) is a major component of the Gram-negative bacteria affects cells of the...
Rationale: Literature has implicated lung inflammation as a risk factor for acute cardiovascular (C...
<p><i>(</i><b><i>A</i></b><i>)</i> Time course of thrombin-induced lung PMN infiltration. Mice were ...
<p>Induction of nmMLCK activity during sepsis leads to activation of Pyk2 which in turn activates β2...
International audienceObstructive sleep apnea is characterized by intermittent hypoxia (IH) which al...
<p><i>(</i><b><i>A</i></b><i>)</i> Effect of ICAM-1 blockade on thrombin-induced lung PMN infiltrati...
During sepsis, endothelial barrier dysfunction contributes to cardiovascular failure, mainly through...
RATIONALE: The myosin light chain kinase gene, MYLK, encodes three proteins via unique promoters, in...
Intermittent hypoxia (IH) alters endothelial function favoring inflammation and could accelerate ath...
Radiotherapy as a primary treatment for thoracic malignancies induces deleterious effects, such as a...
Rationale: Disruption of endothelial barrier function and neutrophil-mediated injury are two major m...
Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction, uncontrolled prol...
Acute lung injuries (ALI) can result from both direct insults (e.g. pneumonia or inhalation injury),...
Objective—The goal of this study was to determine whether tumor necrosis factor (TNF)–induced Src a...
The goal of this study was to investigate the role of MLC phosphatase (MLCP) in a LPS model of acute...
The lipopolysaccharide (LPS) is a major component of the Gram-negative bacteria affects cells of the...
Rationale: Literature has implicated lung inflammation as a risk factor for acute cardiovascular (C...
<p><i>(</i><b><i>A</i></b><i>)</i> Time course of thrombin-induced lung PMN infiltration. Mice were ...
<p>Induction of nmMLCK activity during sepsis leads to activation of Pyk2 which in turn activates β2...
International audienceObstructive sleep apnea is characterized by intermittent hypoxia (IH) which al...
<p><i>(</i><b><i>A</i></b><i>)</i> Effect of ICAM-1 blockade on thrombin-induced lung PMN infiltrati...
During sepsis, endothelial barrier dysfunction contributes to cardiovascular failure, mainly through...
RATIONALE: The myosin light chain kinase gene, MYLK, encodes three proteins via unique promoters, in...
Intermittent hypoxia (IH) alters endothelial function favoring inflammation and could accelerate ath...
Radiotherapy as a primary treatment for thoracic malignancies induces deleterious effects, such as a...
Rationale: Disruption of endothelial barrier function and neutrophil-mediated injury are two major m...
Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction, uncontrolled prol...
Acute lung injuries (ALI) can result from both direct insults (e.g. pneumonia or inhalation injury),...
Objective—The goal of this study was to determine whether tumor necrosis factor (TNF)–induced Src a...
The goal of this study was to investigate the role of MLC phosphatase (MLCP) in a LPS model of acute...
The lipopolysaccharide (LPS) is a major component of the Gram-negative bacteria affects cells of the...
Rationale: Literature has implicated lung inflammation as a risk factor for acute cardiovascular (C...