Trial Evaluating Rosuvastatin (JUPITER), and the Controlled Rosuvastatin Multinational Study

OBJECTIVE — Although statin therapy reduces cardiovascular risk, its relationship with the development of diabetes is controversial. The first study (West of Scotland Coronary Prevention Study [WOSCOPS]) that evaluated this association reported a small protective effect but used nonstandardized criteria for diabetes diagnosis. However, results from subsequent hypothesis-testing trials have been inconsistent. The aim of this meta-analysis is to evaluate the possible effect of statin therapy on incident diabetes. RESEARCH DESIGN AND METHODS — A systematic literature search for random-ized statin trials that reported data on diabetes through February 2009 was conducted using specific search terms. In addition to the hypothesis-generating data from WOSCOPS, hypothe-sis-testing data were available from the Heart Protection Study (HPS), the Long-Term Interven-tion with Pravastatin in Ischemic Disease (LIPID) Study, the Anglo-Scandinavian Cardia