Add to ORKGAbstract: Aberrant sialylation is closely associated with the malignant phenotype of cancer cells including metastatic potential and invasiveness. However, its biological significance and molecular mechanisms have yet to be fully elucidated. To determine causes and consequences, we have focused attention on mammalian sialidases, which cleave sialic acids from gangliosides and glycoproteins. The four types of human sialidases identified to date behave in different manners during carcinogenesis. One, found in the lysosomes, shows down-regulation in cancers, promoting anchorage-independent growth and contributing to metastatic ability, while another, found in the plasma membranes, exhibits marked up-regulation, resulting in suppression of apop...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Sialic acid residues are frequently located at the terminal positions of glycoconjugate chains of ce...
BACKGROUND: Glycosylation is increasingly recognized as one of the most relevant postranslational mo...
BACKGROUND: Glycosylation is increasingly recognized as one of the most relevant postranslational mo...
BACKGROUND: Aberrant sialylation is a characteristic feature associated with cancer. The four types ...
During malignant transformation, glycosylation is heavily altered compared with healthy tissue due t...
Item does not contain fulltextOver four decades ago, specific tumor characteristics were ascribed to...
Over four decades ago, specific tumor characteristics were ascribed to the increased expression of s...
Sialic acids (SA) are a kind of nine-carbon backbone sugars, serving as important molecules in cell-...
Altered glycosylation is a common feature of cancer cells. It takes a variety of forms, which includ...
Altered glycosylation is a common feature of cancer cells. It takes a variety of forms, which includ...
Glycosphingolipids and glycoproteins play pivotal roles in the complex series of events governing ce...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Sialic acid residues are frequently located at the terminal positions of glycoconjugate chains of ce...
BACKGROUND: Glycosylation is increasingly recognized as one of the most relevant postranslational mo...
BACKGROUND: Glycosylation is increasingly recognized as one of the most relevant postranslational mo...
BACKGROUND: Aberrant sialylation is a characteristic feature associated with cancer. The four types ...
During malignant transformation, glycosylation is heavily altered compared with healthy tissue due t...
Item does not contain fulltextOver four decades ago, specific tumor characteristics were ascribed to...
Over four decades ago, specific tumor characteristics were ascribed to the increased expression of s...
Sialic acids (SA) are a kind of nine-carbon backbone sugars, serving as important molecules in cell-...
Altered glycosylation is a common feature of cancer cells. It takes a variety of forms, which includ...
Altered glycosylation is a common feature of cancer cells. It takes a variety of forms, which includ...
Glycosphingolipids and glycoproteins play pivotal roles in the complex series of events governing ce...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Background Glycosylation is increasingly recognized as one of the most relevant postranslational mod...
Sialic acid residues are frequently located at the terminal positions of glycoconjugate chains of ce...