Add to ORKGAbstract: This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will describe the features of the known subtypes of these RNAs; including sequence characteristics, protein interactors, expression characteristics, biogenesis, and similarity to canonical miRNA pathways. Also their role in regulating gene expression; including mediating translational suppression, will be discussed. We also highlight their potential use as biomarkers, functions in gene regulation and links to disease. Finally, this review will speculate as to the origin and rationale for the conservation of this novel class of noncoding RNAs amongst both prokaryotes a...
Transfer RNA (tRNA) accounts for approximately 10% of total cellular RNA pool and plays a crucial ro...
Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived fr...
ABTRACT: tRNA-derived fragments or tRFs were long considered merely degradation intermediates of ful...
This review will summarise the recent discoveries and current state of research on short noncoding R...
© 2015 by the authors; licensee MDPI, Basel, Switzerland. This review will summarise the recent disc...
High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biolog...
Deep sequencing approaches have revealed multiple types of small RNAs with known and unknown functio...
Deep analysis of next-generation sequencing data unveils numerous small non-coding RNAs with distinc...
The advent of RNA-sequencing (RNA-Seq) technologies has markedly improved our knowledge and expanded...
Beyond their central role in protein synthesis, transfer RNAs (tRNAs) have many other crucial functi...
Until recently, transfer RNAs (tRNAs) were thought to function in protein translation only. However,...
tRNAs have been discovered in the late 1950-ies of the last century and have subsequently been chara...
Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most ab...
The fragments that derive from transfer RNAs (tRNAs) are an emerging category of regulatory RNAs. Kn...
Transfer RNA (tRNA) molecules are most commonly known as the molecular amino acids carriers and also...
Transfer RNA (tRNA) accounts for approximately 10% of total cellular RNA pool and plays a crucial ro...
Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived fr...
ABTRACT: tRNA-derived fragments or tRFs were long considered merely degradation intermediates of ful...
This review will summarise the recent discoveries and current state of research on short noncoding R...
© 2015 by the authors; licensee MDPI, Basel, Switzerland. This review will summarise the recent disc...
High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biolog...
Deep sequencing approaches have revealed multiple types of small RNAs with known and unknown functio...
Deep analysis of next-generation sequencing data unveils numerous small non-coding RNAs with distinc...
The advent of RNA-sequencing (RNA-Seq) technologies has markedly improved our knowledge and expanded...
Beyond their central role in protein synthesis, transfer RNAs (tRNAs) have many other crucial functi...
Until recently, transfer RNAs (tRNAs) were thought to function in protein translation only. However,...
tRNAs have been discovered in the late 1950-ies of the last century and have subsequently been chara...
Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most ab...
The fragments that derive from transfer RNAs (tRNAs) are an emerging category of regulatory RNAs. Kn...
Transfer RNA (tRNA) molecules are most commonly known as the molecular amino acids carriers and also...
Transfer RNA (tRNA) accounts for approximately 10% of total cellular RNA pool and plays a crucial ro...
Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived fr...
ABTRACT: tRNA-derived fragments or tRFs were long considered merely degradation intermediates of ful...