PILAR AMIANO, PHD5,6,7 HEINER BOEING, PHD8 MARIA-DOLORES CHIRLAQUE, MD5,9

OBJECTIVEdAge at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with di-abetes risk. RESEARCHDESIGNANDMETHODSdData were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subco-hort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for di-abetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTSdMean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95%CI 1.04–1.69), 1.09 (0.90–1.31), 0.97 (0.86– 1.10), and 0.85 (0.70–1.03) for women with menopause at ages,40, 40–44, 45–49, and $55 years, respectively, relative to those withmenopause at age 50–54 years. TheHRper SD younger ag