Editorial MicroRNAs in Cancer Management: Big Challenges for Small Molecules

License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In the last decade, the scientific community has been shaken by what we call the “noncoding revolution. ” We have witnessed the discovery of an increasing amount of RNA molecules, which play a critical role in normal physiology as well as disease, without providing any protein product. The smallest regulatory RNA species, known as the ∼22 nucleotide-long microRNAs (miRNAs), were at the forefront of such a revolution. According to the last release of miRNA database (miR-Bas