RESEARCH ARTICLE Clinical Correlates of Mass Effect in Autosomal Dominant Polycystic Kidney Disease

Mass effect from polycystic kidney and liver enlargement can result in significant clinical com-plications and symptoms in autosomal dominant polycystic kidney disease (ADPKD). In this single-center study, we examined the correlation of height-adjusted total liver volume (htTLV) and total kidney volume (htTKV) by CT imaging with hepatic complications (n = 461) and abdominal symptoms (n = 253) in patients with ADPKD. “Mass-effect ” complications were assessed by review of medical records and abdominal symptoms, by a standardized research questionnaire. Overall, 91.8 % of patients had 4 or more liver cysts on CT scans. Polycystic liver disease (PLD) was classified as none or mild (htTLV < 1,600 mL/m); moder-ate (1,600 htTLV <3,200mL/m); and severe (htTLV 3,200 mL/m). The prevalence of moderate and severe PLD in our patient cohort was 11.7 % (n = 54/461) and 4.8 % (n = 22/ 461), respectively, with a female predominance in both the moderate (61.1%) and sever