Add to ORKGGermline mutations in the NF1 tumor suppressor gene cause neurofibromatosis type 1 (NF1), a complex genetic disorder with a high predisposition of numerous skeletal dysplasias including short stature, osteoporosis, kyphoscoliosis, and fracture non-union (pseudoarthrosis). We have developed murine models that phenocopy many of the skeletal dysplasias observed in NF1 patients, including reduced bone mass and fracture non-union. We also show that the development of these skeletal manifestations requires an Nf1 haploinsufficient background in addition to nullizygous loss of Nf1 in mesenchymal stem/ progenitor cells (MSCs) and/or their progenies. This is replicated in two animal models of NF1, PeriCre+;Nf1flox/2 and Col2.3Cre+;Nf1flox/2mice. Ado...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Germline mutations in the NF1 tumor suppressor gene cause neurofibromatosis type 1 (NF1), a complex ...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder primarily characterized by the format...
Although nullizygous loss of NF1 leads to myeloid malignancies, haploinsufficient loss of NF1 (Nf1) ...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder primarily characterized by the format...
Indiana University-Purdue University Indianapolis (IUPUI)Skeletal manifestations including short sta...
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease resulting from inactivating ...
Abstract: Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by mutations in the...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder primarily characterized by the format...
BACKGROUND: Bowing and/or pseudarthrosis of the tibia is a known severe complication of neurofibroma...
<div><p>Bone fragility due to osteopenia, osteoporosis or debilitating focal skeletal dysplasias is ...
BACKGROUND: Bowing and/or pseudarthrosis of the tibia is a known severe complication of neurofibroma...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Germline mutations in the NF1 tumor suppressor gene cause neurofibromatosis type 1 (NF1), a complex ...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder primarily characterized by the format...
Although nullizygous loss of NF1 leads to myeloid malignancies, haploinsufficient loss of NF1 (Nf1) ...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder primarily characterized by the format...
Indiana University-Purdue University Indianapolis (IUPUI)Skeletal manifestations including short sta...
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease resulting from inactivating ...
Abstract: Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by mutations in the...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder primarily characterized by the format...
BACKGROUND: Bowing and/or pseudarthrosis of the tibia is a known severe complication of neurofibroma...
<div><p>Bone fragility due to osteopenia, osteoporosis or debilitating focal skeletal dysplasias is ...
BACKGROUND: Bowing and/or pseudarthrosis of the tibia is a known severe complication of neurofibroma...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...
Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during...