Short CommuniCation www.landesbioscience.com Communicative & integrative Biology e28129-1

Vesicular transport along the endocytic pathway involves such processes as endosomal maturation and fusion with lysosomes. During this transport, a myriad of mechanisms act in concert to ensure that the vesicle content is sorted correctly. Governing sev-eral of these mechanisms are the endosomal tethering complexes CORVET and HOPS, both built on the same Vps-C core. In yeast, the core consists of the subunits Vps11, Vps16, Vps18 and Vps33. The CORVET complex is defined by the two accessory subunits Vps3 and Vps8, while the HOPS complex is defined by the accessory proteins Vps39 and Vps41. Both complexes are evolutionary conserved and homologs have been found in mam-mals (for reviews see (1,2)). Among their interaction partners are the ERM proteins, which have been shown to associate with the core subunit Vps11 (3). ERM proteins are known as organiz-ers of the plasma membrane and connect transmembrane an