STUDY PROTOCOL Open Access Effect of oral sodium bicar proceeding to renal replacement therapy across groups. Adverse events, such as worsening of arterial hypertension TRIALS

Full list of author information is available at the end of the articledue to the additional sodium consumption, will be accurately monitored. Discussion: We hypothesize that sufficiently balanced acid–base homeostasis leads to a reduction of decline of renal function in patients with chronic kidney disease. The concept of an exogenous bicarbonate supplementation to substitute the lacking endogenous bicarbonate has existed for a long time, but has never been investigated sufficiently to state clear treatment guidelines