Add to ORKGIntroduction: Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflexibility have been implicated in the etiology of type 2 diabetes (T2D), yet their interrelationship remains speculative. We investigated these interrelationships in a group of T2D and obese normoglycemic control subjects. Methods: 49 non-insulin dependent male T2D patients and 54 male control subjects were enrolled, and a hyperinsulinemic-euglycemic clamp and indirect calorimetry were performed. A muscle biopsy was taken and intramyocellular lipid (IMCL
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability....
Type 2 diabetic patients are characterized by a decreased fat oxidative capacity and high levels of ...
<div><p>About 80% of patients with type 2 diabetes are classified as overweight. However, only about...
Introduction: Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflex...
Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflexibility have b...
Aims/hypothesis: Mitochondrial dysfunction and increased intramyocellular lipid (IMCL) content have ...
OBJECTIVE: Several lines of evidence support a potential role of skeletal muscle mitochondrial dysfu...
Background: Diabetes mellitus (DM) is one of the most prevalent chronic diseases, and its prevalence...
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability....
Type 2 diabetic patients are characterized by a decreased fat oxidative capacity and high levels of ...
<div><p>About 80% of patients with type 2 diabetes are classified as overweight. However, only about...
Introduction: Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflex...
Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflexibility have b...
Aims/hypothesis: Mitochondrial dysfunction and increased intramyocellular lipid (IMCL) content have ...
OBJECTIVE: Several lines of evidence support a potential role of skeletal muscle mitochondrial dysfu...
Background: Diabetes mellitus (DM) is one of the most prevalent chronic diseases, and its prevalence...
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability....
Type 2 diabetic patients are characterized by a decreased fat oxidative capacity and high levels of ...
<div><p>About 80% of patients with type 2 diabetes are classified as overweight. However, only about...