DNA methylation is a mechanism by which cells control gene expression, and cell-specific genes often exhibit unique patterns of DNA methylation. We previously reported that the mouse insulin-2 gene (Ins2) promoter has three potential methylation (CpG) sites, all of which are unmethylated in insulin-producing cells but methylated in other tissues. In this study we examined Ins2 exon 2 and found a similar tissue-specific methylation pattern. These methylation patterns can differentiate between DNA from insulin-producing beta cells and other tissues. We hypothesized that damaged beta cells release their DNA into circulation at the onset of type 1 diabetes mellitus (T1DM) and sought to develop a quantitative methylation-specific polymerase chai...
Abstract Background The early detection of type 1 diabetes (T1D) largely depends on a reliable appro...
The identification of individuals with a high risk of developing type 2 diabetes (T2D) is fundamenta...
The identification of individuals with a high risk of developing type 2 diabetes (T2D) is fundamenta...
DNA methylation is a mechanism by which cells control gene expression, and cell-specific genes often...
<div><p>DNA methylation is a mechanism by which cells control gene expression, and cell-specific gen...
<div><p>The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destru...
The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destruction of...
The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destruction of...
The death of islet β cells is thought to underlie the pathogenesis of virtually all forms of diabete...
<p>(A) Genomic DNA samples from mouse muscle, liver, kidney, blood, brain, spleen, whole pancreas, p...
Assessment of specific beta-cell death can be used to determine the quality and viability of pancrea...
<p>(A) A diagram of the three luciferase reporter plasmids used to test the effect of methylation on...
Diabetic prevalence is at speedy increase globally. Previous studies stated that other than genetics...
BACKGROUND:Insulin is a critical component of metabolic control, and as such, insulin gene expressio...
Background: Insulin is a critical component of metabolic control, and as such, insulin gene expressi...
Abstract Background The early detection of type 1 diabetes (T1D) largely depends on a reliable appro...
The identification of individuals with a high risk of developing type 2 diabetes (T2D) is fundamenta...
The identification of individuals with a high risk of developing type 2 diabetes (T2D) is fundamenta...
DNA methylation is a mechanism by which cells control gene expression, and cell-specific genes often...
<div><p>DNA methylation is a mechanism by which cells control gene expression, and cell-specific gen...
<div><p>The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destru...
The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destruction of...
The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destruction of...
The death of islet β cells is thought to underlie the pathogenesis of virtually all forms of diabete...
<p>(A) Genomic DNA samples from mouse muscle, liver, kidney, blood, brain, spleen, whole pancreas, p...
Assessment of specific beta-cell death can be used to determine the quality and viability of pancrea...
<p>(A) A diagram of the three luciferase reporter plasmids used to test the effect of methylation on...
Diabetic prevalence is at speedy increase globally. Previous studies stated that other than genetics...
BACKGROUND:Insulin is a critical component of metabolic control, and as such, insulin gene expressio...
Background: Insulin is a critical component of metabolic control, and as such, insulin gene expressi...
Abstract Background The early detection of type 1 diabetes (T1D) largely depends on a reliable appro...
The identification of individuals with a high risk of developing type 2 diabetes (T2D) is fundamenta...
The identification of individuals with a high risk of developing type 2 diabetes (T2D) is fundamenta...