against the Influenza A Virus H1N1

Copyright © 2014 Dalya Al-Saad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Influenza virus fluAH1N1 still remains a target for its inhibitionwith smallmolecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1. “Dedicated to the CINMPIS on the occasion of its 20th anniversary” 1