Activation of Toll-like receptors (TLRs) by pathogens triggers cytokine production and T cell activation, immune defense mechanisms that are linked to immunopathology. Here we show that IFN-γ production by CD4+ TH1 cells during mucosal responses to the protozoan parasite Toxoplasma gondii results in dysbiosis and the elimination of Paneth cells. Paneth cell death led to loss of antimicrobial peptides and occurred in conjunction with uncontrolled expansion of the Enterobacteriaceae family of Gram-negative bacteria. The expanded intestinal bacteria were required for the parasite-induced intestinal pathology. The investigation of cell type-specific factors regulating TH1 polarization during T. gondii infection identified the T cell intrinsic T...
Protective immunity to Toxoplasma gondii depends on innate immune activation and the establishment o...
Innate recognition of invading intracellular pathogens is essential for regulating robust and rapid ...
ABSTRACT Interleukin-1 (IL-1) functions as a key regulator of inflammation and innate immunity. The...
Activation of Toll-like receptors (TLRs) by pathogens triggers cytokine production and T cell activa...
Activation of Toll-like receptors (TLRs) by pathogens triggers cytokine production and T cell activa...
The single layer of epithelial cells that line the intestinal tract provides both a physiologic and ...
Paneth cells constitutively produce antimicrobial peptides and growth factors that allow for intesti...
Toxoplasmagondii is an intracellular parasite that has to cope with the microbicidal actions of IFNγ...
The classic anti-viral cytokine interferon-β (IFN-β) can be induced during parasitic infection, but ...
Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness. Infection is ini...
Toxoplasma gondii is an intracellular protozoan parasite that is the etiologic agent of toxoplasmosi...
SummaryToxoplasma gondii is a universally distributed pathogen that infects over one billion people ...
Abstract Background Toxoplasma gondii can invade and replicate in all nucleated cells in a wide rang...
Early innate response of intestinal epithelial cells is the first line defense against enteric patho...
The gut epithelial barrier is a strategic place to prevent, or at least to limit, parasite dissemina...
Protective immunity to Toxoplasma gondii depends on innate immune activation and the establishment o...
Innate recognition of invading intracellular pathogens is essential for regulating robust and rapid ...
ABSTRACT Interleukin-1 (IL-1) functions as a key regulator of inflammation and innate immunity. The...
Activation of Toll-like receptors (TLRs) by pathogens triggers cytokine production and T cell activa...
Activation of Toll-like receptors (TLRs) by pathogens triggers cytokine production and T cell activa...
The single layer of epithelial cells that line the intestinal tract provides both a physiologic and ...
Paneth cells constitutively produce antimicrobial peptides and growth factors that allow for intesti...
Toxoplasmagondii is an intracellular parasite that has to cope with the microbicidal actions of IFNγ...
The classic anti-viral cytokine interferon-β (IFN-β) can be induced during parasitic infection, but ...
Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness. Infection is ini...
Toxoplasma gondii is an intracellular protozoan parasite that is the etiologic agent of toxoplasmosi...
SummaryToxoplasma gondii is a universally distributed pathogen that infects over one billion people ...
Abstract Background Toxoplasma gondii can invade and replicate in all nucleated cells in a wide rang...
Early innate response of intestinal epithelial cells is the first line defense against enteric patho...
The gut epithelial barrier is a strategic place to prevent, or at least to limit, parasite dissemina...
Protective immunity to Toxoplasma gondii depends on innate immune activation and the establishment o...
Innate recognition of invading intracellular pathogens is essential for regulating robust and rapid ...
ABSTRACT Interleukin-1 (IL-1) functions as a key regulator of inflammation and innate immunity. The...