Add to ORKGImmune aging is best known for its immune defects that increase susceptibility to infec-tions and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in the elderly. Why an immune system that suboptimally responds to exogenous antigen fails to maintain tolerance to self-antigens appears to be perplexing. In this review, we will discuss age-associated devi-ations in the immune repertoire and the regulation of signaling pathways that may shed light on this conundrum
Abstract Compromised immunity contributes to the decreased ability of the elderly to control infecti...
Adaptive immunity undergoes severe deterioration with age and represents the main problem in the eld...
An age-related decline in immune functions, referred to as immunosenescence, is partially responsibl...
López-Larrea have contributed equally to this work. Beyond midlife, the immune system shows aging fe...
Major advances in preventing, delaying, or curing individual pathologies are responsible for an incr...
There is evidence of declining effectiveness of the immune system with aging. This must reflect a di...
It is now becoming apparent that the immune system undergoes age-associated alterations, which accum...
The immune system defends against infection, but older people paradoxically suffer not only from fai...
Recognising invading foreign organisms, preventing their spread and ultimately clearing them from th...
With increasing age the human immune system undergoes characteristic changestermed immunosenescence,...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75006/1/j.1753-4887.1995.tb01521.x.pd
Abstract Introduction: Aging causes several changes in the immune system, although immune aging is ...
Abstract During the past century, humans have gained more years of average life expectancy than in t...
Ageing is the greatest challenge that health-care systems will have to deal with this century. This ...
INTRODUCTION: Aging involves various complex cellular and molecular changes, including a general dec...
Abstract Compromised immunity contributes to the decreased ability of the elderly to control infecti...
Adaptive immunity undergoes severe deterioration with age and represents the main problem in the eld...
An age-related decline in immune functions, referred to as immunosenescence, is partially responsibl...
López-Larrea have contributed equally to this work. Beyond midlife, the immune system shows aging fe...
Major advances in preventing, delaying, or curing individual pathologies are responsible for an incr...
There is evidence of declining effectiveness of the immune system with aging. This must reflect a di...
It is now becoming apparent that the immune system undergoes age-associated alterations, which accum...
The immune system defends against infection, but older people paradoxically suffer not only from fai...
Recognising invading foreign organisms, preventing their spread and ultimately clearing them from th...
With increasing age the human immune system undergoes characteristic changestermed immunosenescence,...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75006/1/j.1753-4887.1995.tb01521.x.pd
Abstract Introduction: Aging causes several changes in the immune system, although immune aging is ...
Abstract During the past century, humans have gained more years of average life expectancy than in t...
Ageing is the greatest challenge that health-care systems will have to deal with this century. This ...
INTRODUCTION: Aging involves various complex cellular and molecular changes, including a general dec...
Abstract Compromised immunity contributes to the decreased ability of the elderly to control infecti...
Adaptive immunity undergoes severe deterioration with age and represents the main problem in the eld...
An age-related decline in immune functions, referred to as immunosenescence, is partially responsibl...