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Adipose tissue can be considered a multi-depot organ with extremely dynamic properties. Nutritional and environmental cues can strongly affect the cellular com-position of this tissue and, as a result, pro-mote the remodeling of the whole organ. A positive energy balance and cold exposure induce the growth and transformation of existing adipocytes and the formation of new cells. Both conditions induce the concomitant development of the vascu-lar network to nourish the newly formed adipocytes.1 Recently, the attention of many researchers has been focused on the mechanisms underlying the emergence o