ORIGINAL RESEARCH Safety and Effectiveness of Switching from a Basal- only to Biphasic Insulin Aspart 30 Insulin Regimen

The Author(s) 2013. This article is published with open access at Springerlink.com Purpose: This sub-analysis of the A1chieve study evaluated the safety and effectiveness of changing from a basal-only insulin regimen to biphasic insulin aspart 30. Methods: A1chieve was an international, multicenter, prospective, open-label, non-interventional, 24-week study in people with type 2 diabetes mellitus starting/switching to therapy with biphasic insulin aspart 30, insulin detemir, or insulin aspart (alone/in combination) in routine clinical practice. This sub-analysis evaluated the safety and effectiveness of switching from basal insulin with either insulin glargine (GLA group) or insulin neutral protamine Hagedorn (NEU group) to biphasic insulin aspart 30. Results: A total of 2,818 participants received biphasic insulin aspart 30 (1,395 in the GLA group and 1,423 in the NEU group). After 24 weeks of treatment, there were significant reductions in the proportion of patients with at least one hypoglycemia event: total [baseline vs. 24 weeks: 15.5 % vs. 9.7 % (p\0.001) and 12.3% vs. 9.9 % (p\0.05), in NEU and GLA groups, respectively], major [2.5 % vs. 0.08 % (p\0.001) J. Hadda