RESULTS

The goal was to develop a new index of insulin sensitivity in patients with type 1 diabetes estimated from continuous glucose monitoring (CGM) and subcutaneous insulin delivery data under carefully controlled conditions. RESEARCH DESIGN AND METHODS The database consists of 12 subjects with type 1 diabetes, studied during break-fast, lunch, and dinner, in a clinical research unit, wearing both subcutaneous insulin pump and CGM device. Frequent blood samples were drawn for mea-surements of plasma glucose and insulin concentrations in order to estimate insulin sensitivity with the oral minimal model (SI MM). The new index of insulin sensitivity (SI SP) was calculated with a simple algebraic formula for each meal, using only CGM and insulin pump data and compared with SI MM