RESEARCH ARTICLE Open Access Efficacy and tolerability of

Full list of author information is available at the end of the articleincluding those with irritable bowel syndrome, complain of gas-related symptoms, e.g. bloating, abdominal disten-tion, and flatulence [1]. Indeed, more than 20 % of the gen-eral population suffers from abdominal pain or discomfort and 16 % from bloating or distension [2] with no evidence of any inflammatory, anatomic, metabolic or neoplastic process that explains the subject’s symptoms. Intestinal of life, even in pediatric age [3]. The mechanism underlying gas-related disorders is not well understood. As a result, the best treatment is still not well defined [4,5]. Bloating is the sensation of trapped gas and tightness in the abdomen which is exacerbated by meals and fluctuates in intensity during the day. It may be associated with distension (an objective increase in waist size) and flatulence. Flatulence or gas build up in the intestine is typically caused by the fermentation of undigested food and may cause voluntary or involuntary passing of gas [6]