Add to ORKGThe development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic strategy. Problems facing the develop-ment of effective and safe caspase therapeutics will also be addressed
Caspases are a family of endoproteases that provide critical links in cell regulatory networks contr...
Inflammatory caspases-1, -4, and -5 play critical roles in mediating the innate immune response to p...
Mounting evidence suggests the involvement of caspases in the disease process associated with Alzhei...
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy ...
Abstract Caspases are an evolutionary conserved family of cysteine-dependent proteases that are invo...
Mapping of the human and other eukaryotic genomes has provided the pharmacological industry with exc...
This review provides an overview of the biochemistry and activation of' inflammatory caspases, and f...
1. Apoptosis is an essential process to remove excess, unwanted and harmful cells and maintain homeo...
Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in c...
Abstract. Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their act...
Caspases are intracellular proteases that participate in apoptotic pathways in mammalian cells, incl...
AbstractRecent studies have established that members of the caspase protease family are essential co...
180 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.Programmed cell death, also k...
Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is...
Although apoptosis plays a critical role in molding the CNS into its final appearance and function, ...
Caspases are a family of endoproteases that provide critical links in cell regulatory networks contr...
Inflammatory caspases-1, -4, and -5 play critical roles in mediating the innate immune response to p...
Mounting evidence suggests the involvement of caspases in the disease process associated with Alzhei...
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy ...
Abstract Caspases are an evolutionary conserved family of cysteine-dependent proteases that are invo...
Mapping of the human and other eukaryotic genomes has provided the pharmacological industry with exc...
This review provides an overview of the biochemistry and activation of' inflammatory caspases, and f...
1. Apoptosis is an essential process to remove excess, unwanted and harmful cells and maintain homeo...
Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in c...
Abstract. Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their act...
Caspases are intracellular proteases that participate in apoptotic pathways in mammalian cells, incl...
AbstractRecent studies have established that members of the caspase protease family are essential co...
180 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.Programmed cell death, also k...
Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is...
Although apoptosis plays a critical role in molding the CNS into its final appearance and function, ...
Caspases are a family of endoproteases that provide critical links in cell regulatory networks contr...
Inflammatory caspases-1, -4, and -5 play critical roles in mediating the innate immune response to p...
Mounting evidence suggests the involvement of caspases in the disease process associated with Alzhei...