Purpose: Radiofrequency ablation (RFA) is a minimally invasive energy delivery technique increasingly used for focal therapy to eradicate localized disease. RFA-induced tumor-cell necrosis generates an immunogenic source of tumor antigens known to induce antitumor immune responses. However, RFA-induced antitumor immunity is insufficient to control metastatic progression. We sought to characterize (a) the role of RFA dose on immunogenic modulation of tumor and generation of immune responses and (b) the potential synergy between vaccine immunotherapy and RFA aimed at local tumor control and decreased systemic progression. Experimental Design: Murine colon carcinoma cells expressing the tumor-associated (TAA) carcinoembryonic antigen (CEA) (MC...
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and t...
PURPOSE: To assess the usefulness of combining hyperthermia with a DNA repair inhibitor (double-stra...
Purpose: Most of the patients with advanced colorectal cancer will develop liver metastasis, even af...
PURPOSE: Radiofrequency ablation (RFA) is a minimally invasive energy delivery technique increasingl...
Radiofrequency ablation (RFA) is a minimally invasive energy delivery technique increasingly used fo...
The enhancement of immune response against tumor antigens has shown some efficacy when used as a sin...
Purpose While surgical resection is a cornerstone of cancer treatment, local and distant recurrences...
<div><p>Purpose</p><p>While surgical resection is a cornerstone of cancer treatment, local and dista...
<p>CEA-Tg mice (<i>n</i> = 5–7/group) received MC38-CEA<sup>+</sup> cells on day 0 (right flank s.c....
While surgical resection is a cornerstone of cancer treatment, local and distant recurrences continu...
International audienceRadiofrequency ablation (RFA) of colorectal liver metastases activates a speci...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and I...
<p>Female C57BL/6 mice (<i>n</i> = 8–10/group) were injected s.c. on day 0 with MC38-CEA<sup>+</sup>...
<p>MC38-CEA<sup>+</sup> cells were transplanted on day 0 on the right flank of CEA-Tg mice (<i>n</i>...
[[abstract]]PURPOSE: In this study, we hypothesized that systemic antitumor immunity might be enhanc...
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and t...
PURPOSE: To assess the usefulness of combining hyperthermia with a DNA repair inhibitor (double-stra...
Purpose: Most of the patients with advanced colorectal cancer will develop liver metastasis, even af...
PURPOSE: Radiofrequency ablation (RFA) is a minimally invasive energy delivery technique increasingl...
Radiofrequency ablation (RFA) is a minimally invasive energy delivery technique increasingly used fo...
The enhancement of immune response against tumor antigens has shown some efficacy when used as a sin...
Purpose While surgical resection is a cornerstone of cancer treatment, local and distant recurrences...
<div><p>Purpose</p><p>While surgical resection is a cornerstone of cancer treatment, local and dista...
<p>CEA-Tg mice (<i>n</i> = 5–7/group) received MC38-CEA<sup>+</sup> cells on day 0 (right flank s.c....
While surgical resection is a cornerstone of cancer treatment, local and distant recurrences continu...
International audienceRadiofrequency ablation (RFA) of colorectal liver metastases activates a speci...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and I...
<p>Female C57BL/6 mice (<i>n</i> = 8–10/group) were injected s.c. on day 0 with MC38-CEA<sup>+</sup>...
<p>MC38-CEA<sup>+</sup> cells were transplanted on day 0 on the right flank of CEA-Tg mice (<i>n</i>...
[[abstract]]PURPOSE: In this study, we hypothesized that systemic antitumor immunity might be enhanc...
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and t...
PURPOSE: To assess the usefulness of combining hyperthermia with a DNA repair inhibitor (double-stra...
Purpose: Most of the patients with advanced colorectal cancer will develop liver metastasis, even af...