RESEARCH ARTICLE MicroRNA-155 as a proinfl n 1

[9]. Peripheral blood mononuclear cells (PBMC) in rheumatoid arthritis (RA) express elevated levels of Dong-gu, Gwangju 501-757, Republic of Korea Full list of author information is available at the end of the articleinflammatory response is specifically initiated by inflammasome activation within monocytes/macro-phages, causing activation of inflammatory cytokines within the joint [2]. miRNA have been identified that appear to be crit-ical for fine-tuning many biological processes, and offers the prospect of multiple targets [4,5]. Emer-ging data suggest that single miRNA species can profoundly alter the phenotype and outcome of im-mune responses [6-8]. miR-155 is crucial for the proinflammatory activation of human myeloid cells and antigen-driven inflammator