Add to ORKGAbstract. The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this disorder have a deletion of chromosome 5q [del(5q)] as the sole karyotypic abnormality. Several genes mapping to the commonly deleted region of the 5q- syndrome have been implicated in disease pathogenesis in recent years. Haploinsufficiency of the ribosomal gene RPS14 has been shown to cause the erythroid defect in the 5q- syndrome. Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q-syndrome patients. Haploinsufficiency of CSNK1A1 leads to hematopoietic stem cell expansion in mice and may play a role in the initial clonal expansion in patients with 5q- syndrome. Moreover, a su...
Chromosome 5q deletions (del[5q]) are common in high-risk (HR) myelodysplastic syndrome (MDS) and ac...
BACKGROUND: Haploinsufficiency of the ribosomal protein S14 RPS14 gene, located in the common del...
In 1974 Herman van den Berghe et al. [1][1] reported a distinct hematologic disorder associated with...
The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this ...
permits unrestricted use, distribution, and reproduction in any medium, provided the original work i...
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, th...
The 5q- syndrome is a distinct hematological disorder with typical laboratory, morphological, cytoge...
Perspective article on myelodysplastic syndrome with deltion 5q. In 1974 Herman van den Berghe et al...
Myelodysplastic syndromes (MDS) represent a heterogeneous group of haematological malignancies. A s...
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, a ...
The myelodysplastic syndrome (MDS) with deletion of chromosome 5q [del(5q)] is a distinct subtype of...
In vitro studies suggest that haploinsufficiency is involved in the pathogenesis of myelodysplastic ...
[Background]: Deletion of chromosome 5q (del(5q)) is the most common karyotypic abnormality in myelo...
Abstract The 5q deletion is a chromosomal abnormality that is observed in a subset of myelodysplasti...
Background : Haploinsufficiency of the ribosomal protein S14 RPS14 gene, located in the common delet...
Chromosome 5q deletions (del[5q]) are common in high-risk (HR) myelodysplastic syndrome (MDS) and ac...
BACKGROUND: Haploinsufficiency of the ribosomal protein S14 RPS14 gene, located in the common del...
In 1974 Herman van den Berghe et al. [1][1] reported a distinct hematologic disorder associated with...
The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this ...
permits unrestricted use, distribution, and reproduction in any medium, provided the original work i...
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, th...
The 5q- syndrome is a distinct hematological disorder with typical laboratory, morphological, cytoge...
Perspective article on myelodysplastic syndrome with deltion 5q. In 1974 Herman van den Berghe et al...
Myelodysplastic syndromes (MDS) represent a heterogeneous group of haematological malignancies. A s...
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, a ...
The myelodysplastic syndrome (MDS) with deletion of chromosome 5q [del(5q)] is a distinct subtype of...
In vitro studies suggest that haploinsufficiency is involved in the pathogenesis of myelodysplastic ...
[Background]: Deletion of chromosome 5q (del(5q)) is the most common karyotypic abnormality in myelo...
Abstract The 5q deletion is a chromosomal abnormality that is observed in a subset of myelodysplasti...
Background : Haploinsufficiency of the ribosomal protein S14 RPS14 gene, located in the common delet...
Chromosome 5q deletions (del[5q]) are common in high-risk (HR) myelodysplastic syndrome (MDS) and ac...
BACKGROUND: Haploinsufficiency of the ribosomal protein S14 RPS14 gene, located in the common del...
In 1974 Herman van den Berghe et al. [1][1] reported a distinct hematologic disorder associated with...