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Diabetic nephropathy (DN) is one of the most common and serious complications of capillaries in patients with diabetes [1]. In recent years, research on the structure and function of the filtration barrier of the glomerulus has focused on the function of podocytes in the occurrence and development of DN [2]. Podocytes are terminally differentiated epithelial cells attached to the glomerular basement membrane, and the alternative podocytic processes between adjacent podocytes con-struct the slit diaphragm, which plays an important role in maintaining the integrity of the filtration barrier structure and function of the glomerulus [3-5]. High glucose contributes to reduced podocyte number and in-duces apoptosis of cultured podoctes and causes albu-minuria and accelerates foot process effacement [2,3,6,7]. At present, there is no satisfactory method o