Research Article Automated Training for Algorithms That Learn from Genomic Data

License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalwork is properly cited. Supervisedmachine learning algorithms are used by life scientists for a variety of objectives. Expert-curated public gene and protein databases are major resources for gathering data to train these algorithms. While these data resources are continuously updated, generally, these updates are not incorporated into publishedmachine learning algorithms which thereby can become outdated soon after their introduction. In this paper, we propose a new model of operation for supervised machine learning algorithms that learn from genomic data. By defining these algorithms in a pipeline in which the training data gathering procedure and the learning process are automated, one can create a system that generates a classifier or predictor using information available from public resources.The proposedmodel is explained using three case studies on SignalP, MemLoci, and ApicoAP in which existing machine learning models are utilized in pipelines. Given that the vast majority of the procedures described for gathering training data can easily be automated, it is possible to transform valuable machine learning algorithms into self-evolving learners that benefit from the ever-changing data available for gene products and to develop new machine learning algorithms that are similarly capable. 1