Add to ORKGBackground: The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical relevance for early detection and/or monitoring of disease recurrence. We developed a systematic multi-step biomarker discovery and verification strategy to identify candidate DNA methylation markers for the blood-based detection of ovarian cancer. Methodology/Principal Findings: We used the Illumina Infinium platform to analyze the DNA methylation status of 27,578 CpG sites in 41 ovarian tumors. We employed a marker selection strategy that emphasized sensitivity by requiring consistency of methylation across tumors, while achieving specificity by excluding markers with methylation in contro
BACKGROUND:Hypermethylation of promoter CpG islands with associated loss of gene expression, and hyp...
Objective: Altered DNA methylation patterns hold promise as cancer biomarkers. In this study we sele...
Aim:To evaluate the triage performance of six host-cell DNA methylation markers derived from two gen...
The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical r...
The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical r...
Background: Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) e...
Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy, largely due to the lac...
Most ovarian cancers, despite improvement in management of cancer, are still diagnosed at an advance...
DNA methylation changes in ovarian cancer patients. In our work we studied DNA methylation changes i...
BACKGROUND:Epithelial ovarian carcinoma is a significant cause of cancer mortality in women worldwid...
Aberrant methylation of multiple promoter CpG islands could be related to the biology of ovarian tum...
Epithelial ovarian carcinoma is a significant cause of cancer mortality in women worldwide and in th...
<div><h3>Background</h3><p>There is an increasing demand for accurate biomarkers for early non-invas...
Ovarian cancer is the most lethal gynaecological cancer. Although having good response to chemothera...
<p>Cancer-specific DNA methylation from the tumor derived fraction of cell free DNA found in blood s...
BACKGROUND:Hypermethylation of promoter CpG islands with associated loss of gene expression, and hyp...
Objective: Altered DNA methylation patterns hold promise as cancer biomarkers. In this study we sele...
Aim:To evaluate the triage performance of six host-cell DNA methylation markers derived from two gen...
The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical r...
The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical r...
Background: Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) e...
Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy, largely due to the lac...
Most ovarian cancers, despite improvement in management of cancer, are still diagnosed at an advance...
DNA methylation changes in ovarian cancer patients. In our work we studied DNA methylation changes i...
BACKGROUND:Epithelial ovarian carcinoma is a significant cause of cancer mortality in women worldwid...
Aberrant methylation of multiple promoter CpG islands could be related to the biology of ovarian tum...
Epithelial ovarian carcinoma is a significant cause of cancer mortality in women worldwide and in th...
<div><h3>Background</h3><p>There is an increasing demand for accurate biomarkers for early non-invas...
Ovarian cancer is the most lethal gynaecological cancer. Although having good response to chemothera...
<p>Cancer-specific DNA methylation from the tumor derived fraction of cell free DNA found in blood s...
BACKGROUND:Hypermethylation of promoter CpG islands with associated loss of gene expression, and hyp...
Objective: Altered DNA methylation patterns hold promise as cancer biomarkers. In this study we sele...
Aim:To evaluate the triage performance of six host-cell DNA methylation markers derived from two gen...