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Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A

Publication date

August 2016

Abstract

Estelle Sontag,* † Viyada Nunbhakdi-Craig, * phosphatases act on tau invitro, the enzymes regulatin

Extracted data

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Lindstedt, Philip R.
Taylor, Ross J.
Rinauro, Dillon J.
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January 2021

© 2021 The Authors. Published by American Chemical Society.Tau is a microtubule-associated protein t...

Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A

Sontag, Estelle
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Lee, Gloria
Bloom, George S.
Mumby, Marc C.

December 1996

AbstractRecently, we reported that a pool of protein phosphatase 2A (PP2A) is associated with microt...

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Utton, M.A.

January 1996

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN010944 / BLDSC - British Library D...

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Mandelkow, Eva
Biernat, J.
Drewes, G.
Gustke, N.
Trinczek, B.
Mandelkow, Eckhard

January 1995

We consider the interactions of tau protein with microtubules from two points of view, phosphorylati...

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Liu, Chang
Goetz, Juergen

January 2013

This review is dedicated to Inge Grundke-Iqbal who laid the foundations of the tau field, by isolati...

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Haesen, Dorien
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Fischer, Itzhak

February 1996

AbstractThe abnormal cytoskeletal organization observed in Alzheimer's disease has been suggested to...

Expression and Purification of N-terminally Acetylated microtubule binding protein Tau

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May 2021

The microtubule-associated protein Tau (MAPT) plays a critical role in many neurodegenerative diseas...

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Johnson, Gail V.W.

January 2005

AbstractThe microtubule-associated protein tau, abundant in neurons, has gained notoriety due to the...

Protein kinase C phosphorylates tau and induces its functional alterations

Hoshi, Minako
Nishida, Eisuke
Miyata, Yoshihiko
Sakai, Hikoichi
Miyoshi, Tomoko
Ogawara, Hiroshi
Akiyama, Tetsu

June 1987

AbstractWe found that tau, one of the major microtubule-associated proteins, is a good substrate for...

Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease

Gong, Cheng-Xin
Grundke-Iqbal, Inge
Damuni, Zahi
Iqbal, Khalid

March 1994

AbstractMicrotubule-associated protein tau is abnormally hyperphosphorylated and forms the major pro...

Phosphorylation and dephosphorylation of tau protein by the catalytic subunit of PKA, as probed by electrophoretic mobility retard

Benítez, María J.
Cuadros, Raquel
Jiménez, Juan S.

April 2022

Background: Tau is a microtubule associated protein that regulates the stability of microtubules and...

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Haj-Yahya, Mahmood
Gopinath, Pushparathinam
Rajasekhar, Kolla
Mirbaha, Hilda
Diamond, Marc I.
Lashuel, Hilal A.

March 2020

The consistent observation of phosphorylated tau in the pathology of Alzheimer's disease has contrib...

Phosphorylation of $Ser^{262}$ strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

Biernat, J.
Gustke, N.
Drewes, G.
Mandelkow, Eckhard
Mandelkow, E.

January 1993

Tau protein, a component of Alzheimer paired helical filaments, can be phosphorylated by several kin...

Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase C gamma 1, Grb2, and Src family kinases

Reynolds, C H
Garwood, C J
Wray, S
Price, C
Kellie, S
Perera, T
Zvelebil, M
Yang, A
Sheppard, P W
Varndell, I M
Hanger, D P
Anderton, B H

June 2008

The microtubule-associated protein tau can associate with various other proteins in addition to tubu...

A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms

Brotzakis, Z. Faidon
Lindstedt, Philip R.
Taylor, Ross J.
Rinauro, Dillon J.
Gallagher, Nicholas C. T.
Bernardes, Gonçalo J. L.
Vendruscolo, Michele

January 2021

© 2021 The Authors. Published by American Chemical Society.Tau is a microtubule-associated protein t...