Comprehensive Detection of Terminal Oligo-Pyrimidine (TOP) Genes in Human Genome

It is known that the translation of most ribosomal proteins and some of translation factors is regulated by the same mechanism. These genes have a terminal oligo-pyrimidine sequence at the 5’-end of mRNA, and are hence called TOP genes. Interestingly, these mRNAs are also known to encode translationally regulated genes. Under normal conditions, most of mRNAs have many ribosomes, and such status is called ‘polysome’. Onc