Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by a selective loss of motor neurons. There is no cure and few effective treatments. The RNA-binding protein TDP-43 contributes to the pathogenesis of ALS. TDP-43 is depleted from the nucleus and accumulates in cytoplasmic aggre-gates in the degenerating neurons and glia of most ALS patients. Furthermore, mutations in the TDP-43 gene cause rare familial and sporadic forms of the disease. Thus, therapeutic strategies targeting TDP-43 may be efficacious. We have used the yeast model system to identify the mechanisms by which TDP
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive moto...
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease with no cure. TAR-DNA...
48 p.-7 fig.-1 graph. abst.Accumulation of TDP-43 in the cytoplasm of diseased neurons is the pathol...
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative condition that affects corticospinal and ...
Amyotrophic lateral sclerosis (ALS) is a devastating and universally fatal neurodegenerative disease...
Developing effective treatment strategies for amyotrophic lateral sclerosis (ALS) that affect upper ...
© 2022 Elsevier Ltd. All rights reserved.ALS is pathologically characterised by cytoplasmic aggregat...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Amyotrophic lateral sclerosis (ALS) is a fatal neurode-generative disorder that causes loss of motor...
Nuclear depletion and formation of cytoplasmic inclusions of the DNA/RNA-binding protein TAR DNA-bin...
Amyotrophic lateral sclerosis (ALS) is a largely sporadic progressive neurodegenerative disease affe...
Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that causes progressive neurodegeneration of ...
# The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Therap...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in the specific l...
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive moto...
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease with no cure. TAR-DNA...
48 p.-7 fig.-1 graph. abst.Accumulation of TDP-43 in the cytoplasm of diseased neurons is the pathol...
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative condition that affects corticospinal and ...
Amyotrophic lateral sclerosis (ALS) is a devastating and universally fatal neurodegenerative disease...
Developing effective treatment strategies for amyotrophic lateral sclerosis (ALS) that affect upper ...
© 2022 Elsevier Ltd. All rights reserved.ALS is pathologically characterised by cytoplasmic aggregat...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Amyotrophic lateral sclerosis (ALS) is a fatal neurode-generative disorder that causes loss of motor...
Nuclear depletion and formation of cytoplasmic inclusions of the DNA/RNA-binding protein TAR DNA-bin...
Amyotrophic lateral sclerosis (ALS) is a largely sporadic progressive neurodegenerative disease affe...
Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that causes progressive neurodegeneration of ...
# The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Therap...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in the specific l...
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive moto...
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease with no cure. TAR-DNA...