Letter to the Editor High or Nonhigh Doses of Proton Pump Inhibitors for Patients with Peptic Ulcer Bleeding?

License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. I read with interest the article entitled “A real world report on intravenous high-dose and nonhigh-dose proton pump inhibitors therapy in patients with endoscopically treated high-risk peptic ulcer bleeding ” [1]. In this study, Lu et al. retrospectively analyzed patients receiving nonhighdose (80mg pantoprazole i.v. bolus followed by i.v. 80mg per day for 3 days) and high-dose proton pump inhibitors (PPI, 80mg pantoprazole i.v. bolus followed by 8mg per hr for 3 days) after obtaining initial hemostasis. After performing case-control matching, they found no statistical difference between the high-dose and nonhigh-dose groups. Therefore, they suggest that both doses of PPI were similar in reducing rebleeding in high-risk patients after successful endoscopi