Diabetes

Impaired angiogenesis and its induced refractory wound lesions are common complications of diabetes. Hy-drogen sulfide (H2S) has been reported to have proan-giogenic effects. We hypothesize that H2S improves diabetic wound healing by restoring endothelial progen-itor cell (EPC) function in type 2 diabetes. db/db Mice were treated with sodium hydrosulfide (NaHS), 4-hydro-xythiobenzamide group (HTB), or saline for 18 days. db/+ Mice were treated with DL-propargylglycine (PAG) or sa-line for 18 days. Plasma H2S levels were significantly decreased in db/db mice and restored in the NaHS and HTB mice compared with the diabetic control group. Wound-closure rates were significantly faster in the NaHS and HTB groups than in the db/db group, in which the PAG group had slower wound-closure rates