Diastolic Function Is Reduced in AdolescentsWith Type 1 Diabetes in Response to Exercise

OBJECTIVEdTo determine whether adolescents with type 1 diabetes have left ventricular functional changes at rest and during acute exercise and whether these changes are affected by metabolic control and diabetes duration. RESEARCHDESIGNANDMETHODSdThe study evaluated 53 adolescents with type 1 diabetes and 22 control adolescents. Baseline data included peak exercise capacity and body composition by dual-energy X-ray absorptiometry. Left ventricular functional parameters were obtained at rest and during acute exercise using magnetic resonance imaging. RESULTSdCompared with nondiabetic control subjects, adolescents with type 1 diabetes had lower exercise capacity (44.76 09 vs. 48.56 1.4mL/kg fat-freemass [FFM]/min; P, 0.05). Stroke volumewas reduced in the diabetes group at rest (1.866 0.04 vs. 2.056 0.07mL/kgFFM; P = 0.02) and during acute exercise (1.896 0.04 vs. 2.176 0.06mL/kg FFM; P = 0.01). Diabetic adolescents also had reduced end-diastolic volume at rest (2.946 0.06 vs. 3.266 0.09 mL/kg FFM; P = 0.01) and during acute exercise (2.786 0.05 vs. 3.096 0.08mL/kg FFM; P = 0.01). End-systolic volume was lower in the diabetic group at rest (1.086 0.03 vs. 1.216 0.04 mL/kg FFM; P = 0.01) but not during acute exercise. Exercise capacity and resting and exercise stroke volumeswere correlatedwit