Metabolic Syndrome, C-Reactive Protein, and Mortality in U.S. Blacks and Whites: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study Diabetes Care 2014;37:2284–2290 | DOI: 10.2337/dc13-2059 OBJECTIVE

We evaluate associations ofmetabolic syndrome (MetS), C-reactive protein (CRP), and a CRP-incorporated definition of MetS (CRPMetS) with risk of all-cause mor-tality in a biracial population. RESEARCH DESIGN AND METHODS We studied 23,998 participants in the Reasons for Geographic and Racial Differ-ences in Stroke (REGARDS) cohort, an observational study of black and white adults ‡45 years old across the U.S. Elevated CRP was defined as ‡3 mg/L and MetS by the revised Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III; ATP III) criteria (three of five components). CRPMetS was defined as presence of three out of six components, with elevated CRP added to ATP III criteria as a sixth compo-nent. Cox models were used to calculate hazard ratios (HRs) for all-cause mortal-ity, and population attributable risk (PAR) was calculated. Stratified analyses based on race and diabetes status were performed. RESULT