The ubiquitin-like modifier (UBL) domain of ubiquitin-like domain proteins (UDPs) interacts specifically with subunits of the 26 S proteasome. A novel UDP, ubiquitin-like domain-containing C-terminal domain phosphatase (UBLCP1), has been identified as an interacting partner of the 26 S proteasome. We determined the high-resolution solution structure of the UBL domain of human UBLCP1 by nuclear magnetic resonance spectroscopy. The UBL domain of hUBLCP1 has a unique b-strand (b3) and b3-a2 loop, instead of the canonical b4 observed in other UBL domains. The molecular topology and secondary structures are different from those of known UBL domains including that of fly UBLCP1. Data from backbone dynamics shows that the b3-a2 loop is relatively ...
Background. Ubiquitin-like domains (UbLs), in addition to being post-translationally conjugated to t...
Post-translational modification of substrates with ubiquitin (Ub) is an essential process across all...
ABSTRACT: The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replicat...
The ubiquitin-like modifier (UBL) domain of ubiquitin-like domain proteins (UDPs) interacts specific...
<div><p>The ubiquitin-like modifier (UBL) domain of ubiquitin-like domain proteins (UDPs) interacts ...
RNA polymerase II C-terminal domain phosphatase 1 containing ubiquitin like domain (UBLCP1) has been...
Ubiquitin-specific proteases (USPs) emerge as key regulators of numerous cellular processes and acco...
DC-UbP/UBTD2 is a ubiquitin (Ub) domain-containing protein first identified from dendritic cells, an...
SummaryThe ubiquitin-associated (UBA) domain is one of the most frequently occurring motifs that rec...
SummaryThe 26S proteasome proteolyses ubiquitylated proteins and is assembled from a 20S proteolytic...
International audienceUbiquitin-binding domains (UBDs) provide specificity to the ubiquitin system, ...
Human Ddi2 and his homologues are scarcely explored family of ubiquitin- like/ubiquitin-associated d...
AbstractUSP4, 11 and 15 are three closely related paralogues of the ubiquitin specific protease (USP...
In eukaryotic cells, the 26S proteasome is responsible for the regulated degradation of intracellula...
Ubiquitin conjugation and deconjugation provides a powerful signalling system to change the fate of ...
Background. Ubiquitin-like domains (UbLs), in addition to being post-translationally conjugated to t...
Post-translational modification of substrates with ubiquitin (Ub) is an essential process across all...
ABSTRACT: The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replicat...
The ubiquitin-like modifier (UBL) domain of ubiquitin-like domain proteins (UDPs) interacts specific...
<div><p>The ubiquitin-like modifier (UBL) domain of ubiquitin-like domain proteins (UDPs) interacts ...
RNA polymerase II C-terminal domain phosphatase 1 containing ubiquitin like domain (UBLCP1) has been...
Ubiquitin-specific proteases (USPs) emerge as key regulators of numerous cellular processes and acco...
DC-UbP/UBTD2 is a ubiquitin (Ub) domain-containing protein first identified from dendritic cells, an...
SummaryThe ubiquitin-associated (UBA) domain is one of the most frequently occurring motifs that rec...
SummaryThe 26S proteasome proteolyses ubiquitylated proteins and is assembled from a 20S proteolytic...
International audienceUbiquitin-binding domains (UBDs) provide specificity to the ubiquitin system, ...
Human Ddi2 and his homologues are scarcely explored family of ubiquitin- like/ubiquitin-associated d...
AbstractUSP4, 11 and 15 are three closely related paralogues of the ubiquitin specific protease (USP...
In eukaryotic cells, the 26S proteasome is responsible for the regulated degradation of intracellula...
Ubiquitin conjugation and deconjugation provides a powerful signalling system to change the fate of ...
Background. Ubiquitin-like domains (UbLs), in addition to being post-translationally conjugated to t...
Post-translational modification of substrates with ubiquitin (Ub) is an essential process across all...
ABSTRACT: The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replicat...