Short Sleep Duration Is Associated With a Blood Pressure Nondipping Pattern in Type 1 Diabetes The DIAPASOM study

OBJECTIVE — To assess whether nocturnal blood pressure dipping status in type 1 diabetes is correlated with specific sleep characteristics and differences in nocturnal glycemic profiles. RESEARCH DESIGN AND METHODS — Twenty type 1 diabetic adult patients un-derwent sleep studies with simultaneous 24-h ambulatory blood pressure monitoring and con-tinuous nocturnal glucose monitoring. RESULTS — Altogether, 55 % of patients exhibited blunted blood pressure dipping. They did not differ from the dipper group in age, BMI, or systolic (SBP) and diastolic (DBP) blood pressure. Total sleep period (TSP) was higher in the dipper group (497 30 vs. 407 44 min for dippers and nondippers, respectively, P 0.001). TSP was correlated with SBP and DBP day-night differences (r 0.44 and 0.49, respectively). Periods of nocturnal hypoglycemia (i.e., % of TSP with glycemia 70 mg/dl) were longer in the dipper group (8.1 10.7 vs. 0.1 0.4 % for dippers and nondippers, respectively, P 0.02). CONCLUSIONS — Dipping status in type 1 diabetes was associated with longer sleep du-ration and with hypoglycemia unawareness. Diabetes Care 32:1713–1715, 200