Topics
actinBiomolecule
Dictyostelium discoideumEukaryote
chemotaxisOrganisation
plasma membraneAnatomical structure
PtdIns(3,4,5)P3Software
Phosphatidylinositol 3,4,5-trispho-sphate (PtdIns(3,4,5)P3) is a key signaling molecule in chemotaxis, a directed cell migration toward chemo-attractants. PtdIns(3,4,5)P3 is transiently generated by chemotactic stimulation and activates reorganization of the actin cytoskeleton at the leading edge of migrating cells. In a recent study, we demonstrated that PtdIns(3,4,5)P3 directly binds to three members of the actin-based motor protein myosin I (myosin ID, IE and IF) in Dictyostelium discoideum and recruits these proteins to the plasma membrane of the leading edge. The PtdIns(3,4,5)P3-regulate
SummaryDirected cell migration involves signaling events that lead to local accumulation of PI(3,4,5...
Phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulates at the leading edge of migrati...
The role of PI(3,4,5)P3 in Dictyostelium signal transduction and chemotaxis was investigated using t...
Chemotaxis is the result of a refined interplay among various intracellular molecules that process s...
Dictyostelium cells that chemotax towards cAMP produce phosphatidylinositol (3,4,5)-trisphosphate [P...
Phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] is a key regulator of cell signaling th...
AbstractInositol phosphates are well-known signaling molecules, whereas the inositol pyrophosphates,...
AbstractWe have investigated the mechanisms of leading edge formation in chemotaxing Dictyostelium c...
Chemotaxis is the ability of cells to move in the direction of an external gradient of signaling mol...
Understanding cell migration is centrally important to modern cell biology. However, despite years o...
The directional movement of cells in chemoattractant gradients requires sophisticated control of the...
Chemotaxis is a highly coordinated biological system where chemoattractants trigger multiple signal ...
SummaryBackgroundStudies show that high phosphotidylinositol 3,4,5-trisphosphate (PIP3) promotes cyt...
AbstractShallow gradients of chemoattractants, sensed by G protein-linked signaling pathways, elicit...
Chemotaxis is the result of a refined interplay among various intracellular molecules that process s...
SummaryDirected cell migration involves signaling events that lead to local accumulation of PI(3,4,5...
Phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulates at the leading edge of migrati...
The role of PI(3,4,5)P3 in Dictyostelium signal transduction and chemotaxis was investigated using t...
Chemotaxis is the result of a refined interplay among various intracellular molecules that process s...
Dictyostelium cells that chemotax towards cAMP produce phosphatidylinositol (3,4,5)-trisphosphate [P...
Phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] is a key regulator of cell signaling th...
AbstractInositol phosphates are well-known signaling molecules, whereas the inositol pyrophosphates,...
AbstractWe have investigated the mechanisms of leading edge formation in chemotaxing Dictyostelium c...
Chemotaxis is the ability of cells to move in the direction of an external gradient of signaling mol...
Understanding cell migration is centrally important to modern cell biology. However, despite years o...
The directional movement of cells in chemoattractant gradients requires sophisticated control of the...
Chemotaxis is a highly coordinated biological system where chemoattractants trigger multiple signal ...
SummaryBackgroundStudies show that high phosphotidylinositol 3,4,5-trisphosphate (PIP3) promotes cyt...
AbstractShallow gradients of chemoattractants, sensed by G protein-linked signaling pathways, elicit...
Chemotaxis is the result of a refined interplay among various intracellular molecules that process s...
SummaryDirected cell migration involves signaling events that lead to local accumulation of PI(3,4,5...
Phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulates at the leading edge of migrati...
The role of PI(3,4,5)P3 in Dictyostelium signal transduction and chemotaxis was investigated using t...
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