Add to ORKGABSTRACT: Human Hsp90 isoforms are molecular chaper-ones that are often up-regulated in malignances and represent a primary target for Hsp90 inhibitors undergoing clinical evaluation. Hsp90α is a stress-inducible isoform of Hsp90 that plays a significant role in apoptosis and metastasis. Though Hsp90α is secreted into the extracellular space under metastatic conditions, its role in cancer biology is poorly understood. We report that Hsp90α associates with the Aha1 co-chaperone and found this complex to localize in secretory vesicles and at the leading edge of migrating cells. Knockdown of Hsp90α resulted in a defect in cell migration. The functional role of Hsp90α/Aha1 was studied by treating the cells with various novobiocin-based Hsp90 C-...
Over the past decade, heat-shock protein (HSP)90 has begun to draw increasing attention as a novel a...
The molecular chaperone Hsp90 (90 kDa heat-shock protein) is a remarkably versatile protein involved...
The molecular chaperone Hsp90 is an essential and highly abundant central node in the interactome of...
Human Hsp90 isoforms are molecular chaperones that are often up-regulated in malignances and represe...
HSP90 is a vital chaperone protein conserved across all organisms. As a chaperone protein, it correc...
Heat shock protein 90 (HSP90) is a molecular chaperone of numerous oncoproteins. Therefore, cancer c...
AbstractSince initial discovery of the first HSP90 inhibitor over a decade and a half ago, tremendou...
AbstractHSP90, a major molecular chaperone, plays an essential role in the maintenance of several si...
Cells rely on heat shock proteins (HSP) to facilitate and regulate the folding of the substrate prot...
Heat shock protein (HSP90), a highly conserved molecular chaperon, is indispensable for the maturati...
One of the most important aspects of the molecular chaperone Hsp90’s activity is the ATP-ase cycle....
2013-04-15Extracellular heat shock protein-90 (eHsp90) proteins, which include the membrane-bound, r...
90kDa heat shock proteins (HSP90) belong to a family of molecular chaperones involved in the mainten...
Abstract: The molecular chaperone Hsp90 holds great promise as a cancer drug target, despite some of...
HSP90 is released by cancer cells in the tumor microenvironment where it associates with different c...
Over the past decade, heat-shock protein (HSP)90 has begun to draw increasing attention as a novel a...
The molecular chaperone Hsp90 (90 kDa heat-shock protein) is a remarkably versatile protein involved...
The molecular chaperone Hsp90 is an essential and highly abundant central node in the interactome of...
Human Hsp90 isoforms are molecular chaperones that are often up-regulated in malignances and represe...
HSP90 is a vital chaperone protein conserved across all organisms. As a chaperone protein, it correc...
Heat shock protein 90 (HSP90) is a molecular chaperone of numerous oncoproteins. Therefore, cancer c...
AbstractSince initial discovery of the first HSP90 inhibitor over a decade and a half ago, tremendou...
AbstractHSP90, a major molecular chaperone, plays an essential role in the maintenance of several si...
Cells rely on heat shock proteins (HSP) to facilitate and regulate the folding of the substrate prot...
Heat shock protein (HSP90), a highly conserved molecular chaperon, is indispensable for the maturati...
One of the most important aspects of the molecular chaperone Hsp90’s activity is the ATP-ase cycle....
2013-04-15Extracellular heat shock protein-90 (eHsp90) proteins, which include the membrane-bound, r...
90kDa heat shock proteins (HSP90) belong to a family of molecular chaperones involved in the mainten...
Abstract: The molecular chaperone Hsp90 holds great promise as a cancer drug target, despite some of...
HSP90 is released by cancer cells in the tumor microenvironment where it associates with different c...
Over the past decade, heat-shock protein (HSP)90 has begun to draw increasing attention as a novel a...
The molecular chaperone Hsp90 (90 kDa heat-shock protein) is a remarkably versatile protein involved...
The molecular chaperone Hsp90 is an essential and highly abundant central node in the interactome of...