Experimental Crystal data

R factor = 0.053; wR factor = 0.161; data-to-parameter ratio = 19.4. In the title compound, C29H23ClN4O4, the quinazoline-indole system and the indolin-2-one system are each essentially planar, with maximum deviations from their mean planes of 0.150 (2) and 0.072 (2) Å, respectively. The central pyrrolidine ring adopts a twisted conformation on the C—C bond involving the spiro C atoms. Its mean plane forms dihedral angles of 83.37 (9) and 86.56 (8), respectively, with the indole rings of the indolin-2-one and quinazoline-indole systems. In the crystal, molecules are linked via pairs of N—H O hydrogen bonds, forming inversion dimers. The dimers are linked via C—H O hydrogen bonds, forming chains propagating along [001]. Related literature For quinazoline structures, see: Li & Feng (2009); Li et al. (2010); Priya et al. (2011a). For the biological activity o