Functional Status of Thyroid and Cognitive Functions after Menopause

Background: Thyroid activity plays a role in cognition. However, the relation between the functional state of thyroid and neu-ropsychiatric changes proceeding with age among people without clinical symptoms of thyroid dysfunction is still unknown. The aim of this study was analysis of cognitive function levels in reference to thyroid examina-tion: thyroid-stimulating hormone (TSH), total thyroxin (TT4), triiodothyronine (TT3), free thyroxin (FT4), free triiodothyronine (FT3), thyroperoxidase antibodies (TPO-AB), and thyroglobulin antibodies (Tg-AB), TSH recep-tor antibodies (AB-TSHR) in women after menopause. Material/Methods: A group of 383 women was recruited for the study. The inclusion criteria were: minimum two years after the last menstruation and no dementia signs on Montreal Cognitive Assessment (MoCA). Computerized battery of Central Nervous System Vital Signs (CNS VS) test was used to diagnostic cognitive functions. The blood plas-ma values were determined: TSH, FT3, FT4, TT3, TT4, TPO-AB, Tg-AB, and AB-TSHR. Statistical analysis was per-formed using Pearson’s correlation coefficient and analysis of variance in STATISTICA software. Results: In women after menopause, TSH was negatively correlated with NCI results, executive functions, complex at-tention, and cognitive flexibility. FT4 was positively correlated with results of psychomotor speed. TT3 and TT4 were negatively correlated with results of memory and verbal memory. Furthermore, TT4 was negatively cor-related with NCI, executive functions, and cognitive flexibility. TPO-AB was negatively correlated with result