NANO EXPRESS Doxorubicin-loaded cholic v n

lym us of the anticancer drugs (>70%) and the therapeutic doses core-shell structure having a hydrophobic core and a Amjad et al. Nanoscale Research Letters 2012, 7:687 http://www.nanoscalereslett.com/content/7/1/687(amino acids) [12]. Several attempts have been made toKebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysiathat are often very high [2]. Doxorubicin is one of the most successful drugs for targeting a broad range of cancers. Nevertheless, its clinical use is hindered by its side effects, which include cardiotoxicity and acquired drug resistance. To overcome these complications, researchers have placed an emphasis on developing nanoscale anticancer drug car-riers for improving therapeutic efficacy in addition to redu-cing unwanted side effects [3]. hydrophilic shell and, more significantly, inherent stealth. Polymeric micelles seem ideal for the targeted and con-trolled delivery of hydrophobic anticancer drugs, including paclitaxel and doxorubicin [4], in that they significantly in-crease their water solubility, extend their circulation time, passively target tumor tissues [5], increase their bioavail-ability, have tremendous biocompatibility, and are degrad-able in vivo into nontoxic products. Several types of polymer blocks can be used to form micelles, of which the most studied include poly(α-hydroxy esters) [6] (such as polylactide [7], polyglycolide [8], and poly(ε-caprolactone) [9]), polyether [10], hydrotrophic polymers [11], and poly * Correspondence